Why is it easy to sleep badly when you are under pressure?

2022-07-16 0 By

Why do you Sleep Poorly under Pressure?As the saying goes, “People are light without pressure, but they don’t sleep well under pressure.”Why do you sleep poorly under pressure?What is the mechanism behind it?What are the consequences?Recently, the research results of liping Wang’s team from the Institute of Brain Cognition and Brain Diseases at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences and the Shenzhen-Hong Kong Institute of Brain Science Innovation were published in Neuron, answering these questions.Normal sleep includes rem sleep and non-REM sleep.When people are in rem sleep, their eyes move from side to side, their heart rate increases, their blood pressure increases, and their muscles relax.Most dreams also occur at this stage.Rem sleep has been observed since 1953, but its mechanism and function have remained a mystery for nearly 70 years.The team revealed for the first time the “shared” neural circuitry that regulates REM sleep and visceral fear responses.The discovery of this “shared” loop reveals that REM sleep has a potential “defense against natural enemies” function, provides a possible explanation for THE disorder of REM sleep in psychiatric disorders, and provides a possible target for the diagnosis and treatment of comorbiditis related to sleep disorders and visceral fear disorders.It is often said that a night without dreams is a ‘good night’s sleep’, while nightmares or insomnia is a ‘bad night’s sleep’.Dreaming is a normal physiological part of sleep.To understand dreams, we need to understand the structure of sleep.In 1966, Frederick Snyder, an American psychsiologist, proposed that REM sleep might act as a “sentinel function”.The hypothesis is that periodic REM sleep is often followed by short awakenings, allowing animals to detect danger in their environment.However, this hypothesis is not supported by experimental evidence.Wang liping’s team has been devoted to the neural mechanism of animal instinctive fear defense behavior.To address this hypothesis, the team designed experiments to investigate whether sleep can trigger instinctive defensive behavior in response to natural predators, and to explore the neural mechanisms behind it.Fox is the natural enemy of mice. In the awake state, the odor of fox urine (TMT) can quickly induce the instinctive fear avoidance behavior of mice.Researchers gave mice TMT stimulation during REM sleep and found that they woke up significantly faster than during non-REM sleep, while stimulating them with a scent that smelled like cinnamon bread or a gas that smelled like rotten eggs had no effect.This suggests that REM sleep can specifically respond to natural enemy stimuli.Pressure can’t sleep the neural mechanisms behind the comprehensive use of independent research and development team of animal eye movement monitoring and endoscopic methods of single neuron imaging, regulation and control of chemical genetics, the team found that non-rem sleep, compared their animal predators during rem sleep smell to stimulate faster awaken mice, prompt rem sleep has the function of potential “defense natural enemy”In addition, a neural circuit projected from CRH neurons in the subthalamic nucleus (mSTN) to the lateral pallidus globus (LGP) in the mouse brain was successfully elucidated, which regulates the response to natural enemy stimuli during REM sleep.The team found that CRH neurons in this neural circuit not only play an important role in maintaining rapid eye movement sleep stability, but are also particularly sensitive to information about the danger of predators.Inhibiting this group of neurons reduced the length of REM sleep and made the mice wake up more slowly to natural predator stimuli.This group of neurons is also involved in the regulation of the fear stimulus of the natural enemy when the animal is awake.This provides experimental evidence for the hypothesis that REM sleep may act as a “sentinel function” and provides a neural mechanism explanation.”Although our instinctive defensive nature may have contributed to poor sleep, as societies evolved, we didn’t have to deal with natural predators.The normally conserved natural enemy defense loop may be used in response to external stimuli such as social stress.The same goes for the occurrence of nightmares, external stress, poor sleep posture, and disease status.”Zeng Yuting, lead author of the paper, said long-term sleep problems can affect mental health and even lead to mental illnesses such as depression.If the function of REM sleep is related to avoidance of natural enemies, then does the structure of REM sleep change in mice under long-term natural enemy stress?In this study, we used rats to simulate chronic long-term stress in mice, and found that chronic stress caused significant changes in the structure of REM sleep in mice, including prolonged REM sleep duration and sleep fragmentation.Inhibition of CRH neuronal activity in mice by chemical genetics eliminated structural changes in REM sleep.”It is evolutionarily important that the same group of neurons regulate both sleep and instinctive defense behaviors, rather than evolving two relatively independent neuroregulatory networks.We can hypothesize that natural selection optimizes existing neural circuits’ shared ‘to improve signal transmission and energy efficiency, rather than choosing more metabolically costly alternatives, such as two distinct circuits.In other words, evolution is like an architect working on an old building rather than redesigning a building from scratch.”Wang Liping, corresponding author of the paper.Basis of fudan university school of medicine, pharmacology, vice President of the head of the department of zhi-li huang said, the study also suggests that “Shared” neural circuits may be Parkinson’s patients to accept subthalamic nuclei deep brain stimulation causes of depression and sleep state change, for a total of suffering from a sleep disorder and instinctive fear disorders related to mental illness treatment provides a potential target.The function of REM sleep has been unclear for the past half century, said Hu Zhian, a professor at the PLA Army Military Medical University.The study suggests that one of the important functions of REM sleep is to “equip individuals with the ability to remain alert and responsive to environmental threats while remaining asleep.”This is a very valuable scientific discovery, which is expected to expand people’s understanding of the functional mechanism of sleep and provide an important scientific basis for understanding the mechanism of sleep disorders.(Source: Chinese Journal of Science)